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Novel Single-dose Broad-spectrum Dog Dewormer Demonstrates Good Efficacy And Is Readily Consumed

Author: Intervet/Schering-Plough Animal Health
Posted: Wednesday 1st December, 2010. 18:04:57

Boxmeer (the Netherlands), November 30, 2010 – The broad-spectrum anthelmintic combination preparation for dogs PLERION® (5 mg pyrantel + 20 mg oxantel + 5 mg praziquantel per kg body weight) is an efficacious and well-tolerated treatment against all important endoparasites, as was demonstrated in a series of controlled experimental and field studies that was recently published in the Veterinary Record*. In addition, because PLERION is formulated as a flavored chewable tablet, the product was readily consumed by the vast majority of dogs.

Linda Horspool BVMS, PhD, DipECVPT, MRCVS, Global Technical Director Companion Animal Pharmaceuticals at Intervet/Schering-Plough Animal Health explains: “Pyrantel, oxantel and praziquantel, the active ingredients of PLERION, are well-established anthelmintics, having been used successfully in humans and animals for decades. The combination of these ingredients in one preparation offers the possibility to eliminate relevant parasites from most dogs in a single treatment. Moreover, the good palatability of the flavored chewable tablets makes PLERION easy to give and helps owners to remember to treat their dogs regularly which contributes to adequate deworming”.

The efficacy, safety and palatability of a single-dose treatment with PLERION were assessed after experimental as well as natural infection with common helminths such as whipworms, tapeworms and roundworms. In five controlled studies (48 treated dogs/49 untreated dogs) and three field studies (30 treated dogs), a total of 127 animals were included. In all comparisons, PLERION-treated dogs had statistically significantly lower worm counts than untreated dogs. Moreover, in treated dogs efficacy against whipworms (Trichuris vulpis) was more than 99 percent after experimental infection and 100 percent after natural infection. For roundworms (Toxocara canis), the corresponding figures were 94 and 100 percent, respectively. For tapeworms (Echinococcus granulosus), the efficacy was more than 99 percent after experimental infection.

The preparation was well-tolerated, evidenced by the finding that treatment of dogs with doses up to 6 times the recommended dose or twice the recommended dose on 3 consecutive days did not result in adverse changes in blood parameters, clinical findings or behavior. In client-owned dogs, PLERION was readily consumed as demonstrated by the fact that 88 percent of dogs spontaneously accepted the tablet. The proportion of spontaneous acceptance appeared higher than the 78 percent that was obtained with another commercially available flavored reference preparation containing pyrantel, febantel and praziquantel.

Worm infestations in dogs are important parasites in terms of prevalence, pathogenicity and, occasionally, zoonotic impact. Therefore, the European Scientific Counsel on Companion Animal Parasites (ESCCAP) has re-emphasized in its 2010 guideline update titled “Worm Control in Dogs and Cats” that veterinarians and pet owners (1) must take measures to protect pets from parasitic infestations, (2) protect the pet population from risks associated with travel and its consequent potential to change local parasite epidemiological situations through the export or import of non-endemic parasite species, and (3) should work together to reduce the risks associated with zoonotic transmission of parasitic diseases.

*Reference
Schmid K, Rohdich N, Zschiesche E, Kok DJ, Allan MJ. Efficacy, safety and palatability of a new broad-spectrum anthelmintic formulation in dogs. Veterinary Record 2010;167:647-651

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