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Switch To Dexdomitor® For Your Pre-med

Author: Janssen Animal Health
Posted: Wednesday 19th January, 2011. 18:35:15

Recent in-depth market research1 into vets’ requirements from a pre-med revealed that the essential attributes include: an excellent safety profile, ease of use and compatibility with other agents, reliability, reduction of the dose of induction agent, contribution to effective analgesia, good value for money together with it being widely used and trusted by experts. For a pre-med that meets these requirements, look no further than the alpha-2 agonist, Dexdomitor® from Janssen Animal Health.

Compared to other sedatives, Dexdomitor reduces the hypotensive effect associated with general anaesthesia2, 3, 4

“Use of anaesthetic agents such as isoflurane can lead to vasodilatation and a fall in arterial blood pressure. The preoperative use of alpha-2 agonists, such as Dexdomitor, counteracts these hypotensive effects by increasing vascular tone. This is in contrast to the preoperative use of acepromazine, which can intensify the vasodilatation, and thus the fall in arterial blood pressure induced by isoflurane,” comments Ed Whittle, veterinary advisor at Janssen Animal Health.

In addition, Dexdomitor reduces the risk of adrenaline-induced arrhythmias 2, 4, 5. Organ perfusion is maintained 2, while the degree of sedation is subject to a ceiling effect 6, and is rapidly reversible with Antisedan®.

Dexdomitor contains only the pharmacologically active isomer of medetomidine, dexmedetomidine2. By removing the inactive isomer, Dexdomitor reduces the hepatic metabolic workload compared with medetomidine, which may reduce the potential for drug interactions – particularly important in anaesthesia when many drugs are used in combination. Furthermore, by removing the inactive isomer which is thought to antagonise the effects of dexmedetomidine, Dexdomitor may produce more predictable and improved sedation and analgesia.6,7

Dexdomitor is easy to use and is licensed for use in dogs i/v and i/m alone, and i/m in combination with butorphanol. In cats it is licensed for use i/m alone, and before ketamine. It can be mixed in the same syringe as torbugesic and/or ketamine. Dexdomitor’s reliable and predictable dose-dependent sedation7, analgesia and muscle relaxation in both cats and dogs smoothes induction and reduces patient stress.4 In addition, it substantially reduces the doses of drugs required to induce and maintain anaesthesia8.

With the supply of acepromazine changing, now may be the time to review your choice of pre-medication for cats and dogs. For further information, please contact your Janssen Animal Health account manager or call 01494 567555.

Dexdomitor contains dexmedetomidine hydrochloride 0.5mg/ml. Legal category POM-V.

Antisedan contains atipamezole hydrochloride 5mg/ml. Legal category POM-V

For more information contact Janssen Animal Health, 50 – 100 Holmers Farm Way, High Wycombe, Bucks, HP12 4EG. Tel 01494 567555, Fax 01494 567556. Email ahealth@its.jnj.com

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