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Farmers May Be Missing Early, All Important Signs For BRD

4 months ago

18th January, 2022 14h52


BRD (bovine respiratory disease) remains a disease of significant impact across the UK costing the UK cattle industry an estimated £80 million per year1, however recent research2 by Ceva Animal Health has identified aspects of disease identification, management and treatment that could be improved.

While the farmers questioned in the research believed that they were quick to identify, diagnose and treat an animal with BRD, which is key to minimising the impact, the disease can be difficult to detect using only visual clinical signs without handling e.g., taking the temperature. Pyrexia (a temperature greater than 39.4ºC) is often the first sign of disease and typically occurs 12-72 hours3,4 before the more visual clinical signs appear. For the visual clinical signs, the first one is often a nasal discharge which occurs about 24 hours after the increase in temperature. The signs then progress to an increased breathing rate and coughing. Only a quarter of those questioned always took the temperature of an apparently sick calf before medicating, which can also be a useful parameter to monitor during recovery. Encouraging close monitoring of feed intake and demeanour, combined with measuring the temperature, can help in the early identification and appropriate treatment of affected animals.

Viruses are often the initial pathogens before a secondary bacterial infection is established. However, it appears that many farmers were uncertain about the causal pathogens for BRD on their farms, although they did correctly identify external factors such as weather changes, poorly designed or ventilated buildings, and management tasks causing stress. Interestingly, farmers reported rarely isolating sick animals despite two-thirds of those questioned stating that they had a formal written protocol for the treatment of BRD and 69% of vets5 recommending that infected animals are isolated during Herd Health Plan Reviews. In an ideal situation, affected animals would be removed from their pen as well as the common airspace, especially if there are likely to be new (and therefore naïve) animals entering the shed.

When it comes to treatment, antibiotics continue to be a mainstay, and will remain so until detection improves, to treat the primary or secondary bacterial infections. The use of a NSAID which helps reduce the pyrexia, pain and inflammation associated with disease and therefore improved demeanour and food intake is generally accepted to be best practice. A quarter of the farmers questioned2 did not use NSAIDs routinely for mild BRD which may delay or complicate the recovery.

There are several NSAIDs available for use in cattle and meloxicam with the benefit of a longer duration of activity is the most commonly used and recommended by cattle vets5. ZELERIS® contains the unique combination of florfenicol and meloxicam in one convenient injection. The dose rate of 1ml/10kg is easy for farmers (and vets) to remember, while the syringeability of ZELERIS is proven to be four times faster than similar treatments, even on cold days6. ZELERIS is supplied in a CLAS® shock-resistant vial7 making ZELERIS well suited for farm conditions.

Kythé Mackenzie BVSc MRCVS, ruminant veterinary advisor at Ceva Animal Health, comments: “BRD remains a significant health and welfare issue for the UK cattle in both the dairy and beef sectors with the associated decrease in longevity and productivity. It is important vets and farmers work together to put prevention and management protocols in place. When treatment is necessary the inclusion of a NSAID has recognised benefits especially in the reduction of pyrexia and pain.”

Top tips for farmers to help prevent, identify and manage BRD:

Ceva Animal Health has launched a ‘Breathe and feel better’ marketing campaign to promote best practice amongst both vets and farmers to help identify, manage and treat BRD on farms. For further information on BRD, visit, contact your Ceva territory manager or our customer services team on 01494 781510.


  1. Barrett D.C. (2000) Veterinary Record 146, 545-550
  2. 16 40 minute telephone interviews with cattle farmers. Mo Gannon Associates, April 2021
  3. Timsit et al (2011) Early detection of bovine respiratory disease in young bulls using reticulo-rumen temperature boluses. The Veterinary Journal 190.1 (2011): 136-142.
  4. Timsit et al (2011) Visually undetected fever episodes in newly received beef bulls at a fattening operation: occurrence, duration, and impact on performance. Journal of animal science.1;89(12):4272-80.
  5. 80 10 minute online interviews with vets who spend at least 50% of their professional time treating cattle. Mo Gannon Associates. July 2021
  6. Achard et al (2017) Comparison of the syringeability of a new fixed combination of florfenicol and meloxicam (Zeleris®) with florfenicol-based products commonly used in bovine respiratory disease (BRD).Poster 00093 presented at EBF
  7. Cavaroc P. J. et al. – Comparative breakage study of injectable anti-infectives vials under vertical drop test by free fall under standardized conditions. IPVS Congress, 2012, 100

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