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Clinical Proof Of NSAID Reduction And More, Through Dietary Means

14 years ago

22nd March, 2010 00h00

Recent studies show that feeding a food enriched with omega-3 fatty acids from fish oils to dogs with osteoarthritis results in:The claim that food can effectively support medical treatment follows in the wake of two published and one in press study in the Journal of the American Veterinary Medicine Association (JAVMA). These demonstrate that omega-3 enriched food (in this case Hill's™ Prescription Diet™ j/d™ Canine) has significant effects on weight bearing and helps reduce NSAID dosage by up to 25 per cent, when fed to dogs with osteoarthritis 1, 2,3. This exciting field of research demonstrates that in dogs the high levels of EPA* from fish oils can down-regulate the cartilage degrading enzyme aggrecanase1. In vitro studies have also identified that EPA resulted in a reduction in the amount of degraded cartilage residue produced4. High levels of omega-3 fatty acids can also help to reduce inflammation5,6. The two studies that were recently published confirm that feeding a diet rich in omega-3 fatty acids, aids in the management of osteoarthritis in dogs2,3. The randomized double blinded controlled trials were carried out over three and six months respectively and involved a total of 165 dogs identified as suffering from mild to moderate osteoarthritis. After collating the results from almost 25,000 trial days, researchers were able to confirm a significant ‘clinical improvement’ from feeding a food fortified with fatty acids. In the first study described in JAVMA, researchers found evidence that omega-3 fatty acids from fish oils resulted in improvements in weight bearing2. Objective measurement using force plate gait analysis demonstrated that dogs fed a test food fortified with fatty acids were seven times as likely to show improved weight bearing compared with dogs fed a control food. In the second study, through a detailed questionnaire, owners also observed significant improvements in their dog’s osteoarthritic condition3. Improvements observed covered the following signs: difficulty in rising from rest, limping, stiffness, soreness when touched, yelping or whimpering in pain, aggression, lagging on walks, reluctance to play and overall activity level. Adrian Pratt, Veterinary Affairs Manager for Hill’s Pet Nutrition, manufacturer of Prescription Diet™ j/d™, which is enriched with omega-3 fatty acids, hailed the results as a breakthrough in the field of nutrigenomics***, “This research points the way to a new model for the management of osteoarthritis, using a clinically proven food to interrupt the cycle of damage and cartilage degradation, alongside graded levels of NSAIDs and proactive programmes to manage weight and adjust exercise routines. Clinicians now have the conclusive proof they need to recommend feeding omega-3 enriched food to ameliorate the signs of osteoarthritis in clients’ pets and to adjust NSAID doses accordingly.” For further information on Hill’sTM Prescription DietTM j/dTM contact your Hill’sTM Territory Manager or call 0800 282438. *EPA – eicosapentaenoic acid ***Nutrigenomics- studying the effects of nutrition on gene expression, References 1. A multicenter study of the effect of a therapeutic food supplemented with fish oil omega-3 fatty acids on the Carpofen dosage in dogs with osteoarthritis. Fritsch A, Allen T, Dodd C, JAVMA in press 2. Evaluation of the effects of dietary supplementation with fish oil omega-3 fatty acids on weight bearing in dogs. Roush J, Cross A, Renberg W, Dodd C, Sixby K, Fritsch A, Allen T, Jewell, Richardson D, Leventhal P, Hahn K, JAVMA Vol 236 No 1, Jan 2010 pp67-73 3. Multicenter veterinary practice assessment of the effects of omega-3 fatty acids on osteoarthritis in dogs. Roush J, Dodd C, Fritsch A, Allen T, Jewell D, Schoenherr W, Richardson D, Leventhal P, Hahn K, JAVMA Vol 236 No 1, Jan 2010 pp 59-66 4. Eicosapentaenoate supplementation abrogates canine articular cartilage degeneration in in vitro explant culture systems, Caterson B, Cramp J, Little C B et al, Hills European Symposium on osteoarthritis and joint health 2005 14-19 5. Dietary modification of inflammation with lipids, P C Calder, Proceedings of the Nutrition Society 2002 345-358 6. Dietary polyunsaturated fatty acids and inflammatory mediator production, James M J, Cleland L G, Gibson R A, Am J Clin Nut 2000: 71 suppl 343S- 358S 7. Vasseur PB, Johnson AL, Budsberg SC, et al. Randomized, controlled trial of the efficacy of carprofen, a nonsteroidal anti-inflammatory drug, in the treatment of osteoarthritis in dogs. J Am Vet Med Assoc 1995; 206 (6): 807-811.

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